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Article

Fibroblasts Drive Metabolic Reprogramming in Pacemaker Cardiomyocytes

25 May 2022

Abstract excerpt

BACKGROUND: The sino atrial node (SAN) is characterized by the microenvironment of pacemaker cardiomyocytes (PCs) encased with fibroblasts. An altered microenvironment leads to rhythm failure. Operable cell or tissue models are either generally lacking or difficult to handle. The biological process behind the milieu of SANs to evoke pacemaker rhythm is unknown. We explored how fibroblasts interact with PCs and...

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PMID: 35611699
DOI: 10.1161/circresaha.121.320301

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