Article
Metastable Atrial State Underlies the Primary Genetic Substrate for MYL4 Mutation-Associated Atrial Fibrillation.
Circulation - 28 Jan 2020
Ghazizadeh Zaniar, Kiviniemi Tuomas, Olafsson Sigurast, Plotnick David, Beerens Manu E, Zhang Kun, Gillon Leah, Steinbaugh Michael J, Barrera Victor, Sui Shannan Ho, Werdich Andreas A, Kapur Sunil, Eranti Antti, Gunn Jarmo, Jalkanen Juho, Airaksinen Juhani, Kleber Andre G, Hollmén Maija, MacRae Calum A
Abstract excerpt
BACKGROUND: Atrial fibrillation (AF) is the most common clinical arrhythmia and is associated with heart failure, stroke, and increased mortality. The myocardial substrate for AF is poorly understood because of limited access to primary human tissue and mechanistic questions around existing in vitro or in vivo models. METHODS: Using an MYH6:mCherry knock-in reporter line, we developed a protocol to generate and...
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