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Article

Suppression of p53 response by targeting p53-Mediator binding with a stapled peptide

1 Apr 2022

Abstract excerpt

DNA-binding transcription factors (TFs) remain challenging to target with molecular probes. Many TFs function in part through interaction with Mediator, a 26-subunit complex that controls RNA polymerase II activity genome-wide. We sought to block p53 function by disrupting the p53-Mediator interaction. Through rational design and activity-based screening, we characterize a stapled peptide, with functional mimics...

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Identifiers

PMID: 35385747
DOI: 10.1016/j.celrep.2022.110630

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