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Article

Metabotropic glutamate receptor 5 knockout rescues obesity phenotype in a mouse model of Huntington's disease.

Scientific reports - 4 Apr 2022

Santos Rebeca P M, Ribeiro Roberta, Ferreira-Vieira Talita H, Aires Rosaria D, de Souza Jessica M, Oliveira Bruna S, Lima Anna Luiza D, de Oliveira Antônio Carlos P, Reis Helton J, de Miranda Aline S, Vieira Erica M L, Ribeiro Fabiola M, Vieira Luciene B

Abstract excerpt

Obesity represents a global health problem and is characterized by metabolic dysfunctions and a low-grade chronic inflammatory state, which can increase the risk of comorbidities, such as atherosclerosis, diabetes and insulin resistance. Here we tested the hypothesis that the genetic deletion of metabotropic glutamate receptor 5 (mGluR5) may rescue metabolic and inflammatory features present in BACHD mice, a...

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Identifiers

PMID: 35379852
DOI: 10.1038/s41598-022-08924-4
PMCID: PMC8980063

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