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Enteroviral 3C protease cleaves N4BP1 to impair the host inflammatory response

10 Dec 2024

Abstract excerpt

Enteroviral 3C protease (3Cpro) is an essential enzyme for viral replication and is responsible for combating the host anti-viral immune response by targeting cellular proteins for cleavage. The identification and characterization of 3Cpro substrates will contribute to our understanding of viral pathogenesis. In this study, we performed a motif search for 3Cpro substrates in the human protein database using FIMO,...

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PMID: 39655957
DOI: 10.1128/jvi.01758-24

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