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Article

An Essential Role of the Universal Polarity Protein, aPKCλ, on the Maintenance of Podocyte Slit Diaphragms

14 Jan 2009

Abstract excerpt

Glomerular visceral epithelial cells (podocytes) contain interdigitated processes that form specialized intercellular junctions, termed slit diaphragms, which provide a selective filtration barrier in the renal glomerulus. Analyses of disease-causing mutations in familial nephrotic syndromes and targeted mutagenesis in mice have revealed critical roles of several proteins in the assembly of slit diaphragms. The...

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PMID: 19142224
DOI: 10.1371/journal.pone.0004194

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Related research

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Research trail→

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An Essential Role of the Universal Polarity Protein, aPKCλ, on the Maintenance of Podocyte Slit DiaphragmsPMID 19142224Read ↗

Neph-Nephrin Proteins Bind the Par3-Par6-Atypical Protein Kinase C (aPKC) Complex to Regulate Podocyte Cell PolaritySemantic proximity Read ↗

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aPKCλ/ι and aPKCζ Contribute to Podocyte Differentiation and Glomerular MaturationSemantic proximity Read ↗

Par3A and Par3B orchestrate podocyte architecture by regulating RhoA levelsSemantic proximity Read ↗

Podocyte polarity signallingSemantic proximity Read ↗

Interaction between PAR-3 and the aPKC-PAR-6 complex is indispensable for apical domain development of epithelial cells.Semantic proximity Read ↗

The WD40 protein Morg1 facilitates Par6-aPKC binding to Crb3 for apical identity in epithelial cells.Semantic proximity Read ↗

KIBRA Modulates Directional Migration of PodocytesSemantic proximity Read ↗

aPKC acts upstream of PAR-1b in both the establishment and maintenance of mammalian epithelial polarity.Semantic proximity Read ↗

Polycystin-1 binds Par3/aPKC and controls convergent extension during renal tubular morphogenesisSemantic proximity Read ↗

Nephrin Signaling in the Podocyte: An Updated View of Signal Regulation at the Slit Diaphragm and BeyondSemantic proximity Read ↗

Dnmbp interacts with Daam1 to facilitate assembly of cadherin-mediated junctions in epithelializing nephric tubulesSemantic proximity Read ↗

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