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Linking Basement Membrane and Slit Diaphragm in Drosophila Nephrocytes

22 May 2024

Abstract excerpt

Key Points Drosophila nephrocytes feature a special basement membrane that may serve to model joint function of the glomerular filtration barrier. Silencing of Drosophila laminin and collagen IV genes reduced the density of slit diaphragms in nephrocytes, showing a direct effect of the matrix. Matrix receptor silencing phenocopied basement membrane disruption, indicating that the matrix guides slit diaphragm...

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PMID: 38776165
DOI: 10.1681/asn.0000000000000400

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