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Juvenile Plasma Factors Improve Organ Function and Survival following Injury by Promoting Antioxidant Response

1 Jan 2022

Abstract excerpt

Studies have shown that factors in the blood of young organisms can rejuvenate the old ones. Studies using heterochronic parabiosis models further reinforced the hypothesis that juvenile factors can rejuvenate aged systems. We sought to determine the effect of juvenile plasma-derived factors on the outcome following hemorrhagic shock injury in aged mice. We discovered that pre-pubertal (young) mice subjected to...

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PMID: 35371607
DOI: 10.14336/ad.2021.0830

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