Article
Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions.
The Journal of experimental medicine - 5 Jul 2021
Ho Theodore T, Dellorusso Paul V, Verovskaya Evgenia V, Bakker Sietske T, Flach Johanna, Smith Lucas K, Ventura Patrick B, Lansinger Olivia M, Hérault Aurélie, Zhang Si Yi, Kang Yoon-A, Mitchell Carl A, Villeda Saul A, Passegué Emmanuelle
Abstract excerpt
While young blood can restore many aged tissues, its effects on the aged blood system itself and old hematopoietic stem cells (HSCs) have not been determined. Here, we used transplantation, parabiosis, plasma transfer, exercise, calorie restriction, and aging mutant mice to understand the effects of age-regulated systemic factors on HSCs and their bone marrow (BM) niche. We found that neither exposure to young...
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