Article

Paternal cardiac injury elicits an inflammatory signal relay to the gonads with intergenerational cardiac effects in vertebrates

2026-08-24

Abstract excerpt

The blood-gonadal barrier protects the germline from parental exposures. A phenomenon known as intergenerational inheritance suggests that, exceptionally, this barrier can be surpassed with consequences for the subsequent generation. Specific diet regimes and early traumatic experiences have been among the chronic stressors shown to be able to lead to intergenerational inheritance in mammals. Less is known about h...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2de9c001-32c6-5a39-9e07-fd86e373db26
DOI: 10.64898/2026.08.22.746193

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Paternal cardiac injury elicits an inflammatory signal relay to the gonads with intergenerational cardiac effects in vertebratesDOI 10.64898/2026.08.22.746193Read

Cross-species single-cell RNA-seq analysis reveals disparate and conserved cardiac and extracardiac inflammatory responses upon heart injurySemantic proximity Read

Stress decreases spermatozoa quality and induces molecular alterations in zebrafish progenySemantic proximity Read

Reciprocal analyses in zebrafish and medaka reveal that harnessing the immune response promotes cardiac regenerationSemantic proximity Read

Multiple cryoinjuries modulate the efficiency of zebrafish heart regeneration.Semantic proximity Read

Estrogen accelerates heart regeneration by promoting inflammatory responses in zebrafishSemantic proximity Read

<i>ankrd1a</i> consistently marks cardiomyocytes bordering the injury or scar area and affects their dedifferentiation during zebrafish heart regeneration after cryoinjurySemantic proximity Read

Molecular evidence of stress-induced acute heart injury in a mouse model simulating posttraumatic stress disorderSemantic proximity Read

Late developing cardiac lymphatic vasculature supports adult zebrafish heart function and regeneration.Semantic proximity Read

Subchronic elevation in ambient temperature drives alterations to the sperm epigenome and accelerates early embryonic development in miceSemantic proximity Read

Intermittent hypoxia promotes functional neuroprotection from retinal ischemia in untreated first-generation offspringSemantic proximity Read

Intergenerational Conditioning via Intermittent Parental Hypoxia Confers Stroke Resilience in OffspringSemantic proximity Read

The number of X chromosomes influences protection from cardiac ischaemia/reperfusion injury in mice: one X is better than twoSemantic proximity Read