Article
Exposure to a youthful circulaton rejuvenates bone repair through modulation of β-catenin.
Nature communications - 19 May 2015
Baht Gurpreet S, Silkstone David, Vi Linda, Nadesan Puviindran, Amani Yasha, Whetstone Heather, Wei Qingxia, Alman Benjamin A
Abstract excerpt
The capacity for tissues to repair and regenerate diminishes with age. We sought to determine the age-dependent contribution of native mesenchymal cells and circulating factors on in vivo bone repair. Here we show that exposure to youthful circulation by heterochronic parabiosis reverses the aged fracture repair phenotype and the diminished osteoblastic differentiation capacity of old animals. This rejuvenation...
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