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Article

Decay-Accelerating Factor Creates an Organ-Protective Phenotype after Hemorrhage in Conscious Rats.

International journal of molecular sciences - 5 Nov 2022

Simovic Milomir O, Falabella Michael J, Le Tuan D, DalleLucca Jurandir J, Li Yansong

Abstract excerpt

Preclinical and clinical studies have shown that traumatic hemorrhage (TH) induces early complement cascade activation, leading to inflammation-associated multiple-organ dysfunction syndrome (MODS). Several previous studies have demonstrated the beneficial effects of complement inhibition in anesthetized (unconscious) animal models of hemorrhage. Anesthetic agents profoundly affect the immune response,...

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Identifiers

PMID: 36362350
DOI: 10.3390/ijms232113563
PMCID: PMC9655774

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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