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Hepatitis B virus biology and life cycle

28 Aug 2020

Abstract excerpt

Hepatitis B virus (HBV) specifically infects hepatocytes and causes severe liver diseases. The HBV life cycle is unique in that the genomic DNA (relaxed-circular partially double-stranded DNA: rcDNA) is converted to a molecular template DNA (covalently closed circular DNA: cccDNA) to amplify a viral RNA intermediate, which is then reverse-transcribed back to viral DNA. The highly stable characteristics of cccDNA...

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PMID: 32866519
DOI: 10.1016/j.antiviral.2020.104925

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