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Article

HBV cccDNA: viral persistence reservoir and key obstacle for a cure of chronic hepatitis B

5 Jun 2015

Abstract excerpt

At least 250 million people worldwide are chronically infected with HBV, a small hepatotropic DNA virus that replicates through reverse transcription. Chronic infection greatly increases the risk for terminal liver disease. Current therapies rarely achieve a cure due to the refractory nature of an intracellular viral replication intermediate termed covalently closed circular (ccc) DNA. Upon infection, cccDNA is...

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PMID: 26048673
DOI: 10.1136/gutjnl-2015-309809

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