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Article

Biogenesis and molecular characteristics of serum hepatitis B virus RNA

20 Oct 2020

Abstract excerpt

HBV is an enveloped DNA virus that replicates its DNA genome via reverse transcription of a pregenomic (pg) RNA intermediate in hepatocytes. Interestingly, HBV RNA can be detected in virus-like particles in chronic hepatitis B (CHB) patient serum and has been utilized as a biomarker for intrahepatic cccDNA activity in treated patients. However, the biogenesis and molecular characteristics of serum HBV RNA remain...

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PMID: 33079954
DOI: 10.1371/journal.ppat.1008945

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