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Structural Basis of the Avian Influenza NS1 Protein Interactions with the Cell Polarity Regulator Scribble

11 Mar 2022

Abstract excerpt

Scribble is a highly conserved regulator of cell polarity, a process that enables the generation of asymmetry at the cellular and tissue level in higher organisms. Scribble acts in concert with Disc-large (Dlg) and Lethal-2-giant larvae (Lgl) to form the Scribble polarity complex, and its functional dysregulation is associated with poor prognosis during viral infections. Viruses have been shown to interfere with...

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PMID: 35336989
DOI: 10.3390/v14030583

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