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Article

HCV NS4B targets Scribble for proteasome-mediated degradation to facilitate cell transformation.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Sept 2016

Hu Bo, Li Shanshan, Zhang Zhanfeng, Xie Shenggao, Hu Yuqian, Huang Xianzhang, Zheng Yi

Abstract excerpt

Hepatitis C virus (HCV) nonstructural protein 4B (NS4B) is a multi-transmembrane protein, but little is known about how NS4B contributes to HCV replication and tumorigenesis. Its C-terminal domain (CTD) has been shown to associate with intracellular membrane, and we have previously shown that NS4B CTD contains a class I PDZ-binding motif (PBM). Here, we demonstrated that NS4B PBM interacts with the PDZ-containing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27315218
DOI: 10.1007/s13277-016-5100-4
PMCID: PMC7097421

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