Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A specificity map for the PDZ domain family.

PLoS biology - 30 Sept 2008

Tonikian Raffi, Zhang Yingnan, Sazinsky Stephen L, Currell Bridget, Yeh Jung-Hua, Reva Boris, Held Heike A, Appleton Brent A, Evangelista Marie, Wu Yan, Xin Xiaofeng, Chan Andrew C, Seshagiri Somasekar, Lasky Laurence A, Sander Chris, Boone Charles, Bader Gary D, Sidhu Sachdev S

Abstract excerpt

PDZ domains are protein-protein interaction modules that recognize specific C-terminal sequences to assemble protein complexes in multicellular organisms. By scanning billions of random peptides, we accurately map binding specificity for approximately half of the over 330 PDZ domains in the human...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding Sites
Share to Caenorhabditis elegans Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to PDZ Domains

Share to Peptides

Share to Protein Structure, Secondary

Share to Proteome

Share to Tumor Suppressor Proteins

Share to Viral Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 18828675
DOI: 10.1371/journal.pbio.0060239
PMCID: PMC2553845

Genes

SCRIB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18828675-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A specificity map for the PDZ domain family.PMID 18828675Read ↗

Comprehensive analysis of all evolutionary paths between two divergent PDZ domain specificities.Semantic proximity Read ↗

Distinct ligand specificity of the Tiam1 and Tiam2 PDZ domains.Semantic proximity Read ↗

Human and primate tumour viruses use PDZ binding as an evolutionarily conserved mechanism of targeting cell polarity regulatorsSemantic proximity Read ↗

Proteome-wide analysis of phospho-regulated PDZ domain interactions through phosphomimetic proteomic peptide phage displaySemantic proximity Read ↗

Rewiring of PDZ domain-ligand interaction network contributed to eukaryotic evolution.Semantic proximity Read ↗

Proteome-scale characterisation of motif-based interactome rewiring by disease mutations.Semantic proximity Read ↗

A combined binary interaction and phenotypic map of C. elegans cell polarity proteins.Semantic proximity Read ↗

Proteome-scale characterisation of motif-based interactome rewiring by disease mutationsSemantic proximity Read ↗

Viral Interactions with PDZ Domain-Containing Proteins—An Oncogenic Trait?Semantic proximity Read ↗

Inferring PDZ domain multi-mutant binding preferences from single-mutant data.Semantic proximity Read ↗

A molecular-properties-based approach to understanding PDZ domain proteins and PDZ ligands.Semantic proximity Read ↗

Domain-mediated protein interaction prediction: From genome to network.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.