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Article

Analysis of the PDZ binding specificities of Influenza A Virus NS1 proteins

19 Jan 2011

Abstract excerpt

The Influenza A virus non-structural protein 1 (NS1) is a multifunctional virulence factor with several protein-protein interaction domains, involved in preventing apoptosis of the infected cell and in evading the interferon response. In addition, the majority of influenza A virus NS1 proteins have a class I PDZ-binding motif at the C-terminus, and this itself has been shown to be a virulence determinant.In the...

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PMID: 21247458
DOI: 10.1186/1743-422x-8-25

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