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Article

The role of DNA methylation and histone modifications in transcriptional regulation in humans.

Sub-cellular biochemistry - 1 Jan 2013

Miller Jaime L, Grant Patrick A

Abstract excerpt

Although the field of genetics has grown by leaps and bounds within the last decade due to the completion and availability of the human genome sequence, transcriptional regulation still cannot be explained solely by an individual's DNA sequence. Complex coordination and communication between a plethora of well-conserved chromatin modifying factors are essential for all organisms. Regulation of gene expression...

Topics

Chromatin
Chromatin Assembly and Disassembly
DNA Methylation
Epigenesis, Genetic
Gene Expression Regulation
Genetic Predisposition to Disease
Histones
Humans
Phenotype
RNA
Transcription, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23150256
DOI: 10.1007/978-94-007-4525-4_13
PMCID: PMC6611551

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