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Epigenetic Therapy: Histone Acetylation, DNA Methylation and Anti-Cancer Drug Discovery

1 Dec 2009

Abstract excerpt

Histone proteins are subject to a diverse range of post-translational modifications which, along with DNA methylation, play a major role in controlling gene expression, cell division, survival and differentiation. Alterations in these chromatin modifications are thought to contribute to important human diseases including cancer. Inhibition of the enzymes that introduce and remove these chromatin modifications is...

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PMID: 20025605
DOI: 10.2174/156800909790192428

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