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Article

A mechanism for epithelial-mesenchymal heterogeneity in a population of cancer cells

10 Feb 2020

Abstract excerpt

Epithelial-mesenchymal heterogeneity implies that cells within the same tumor can exhibit different phenotypes-epithelial, mesenchymal, or one or more hybrid epithelial-mesenchymal phenotypes. This behavior has been reported across cancer types, both in vitro and in vivo, and implicated in multiple processes associated with metastatic aggressiveness including immune evasion, collective dissemination of tumor...

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PMID: 32040502
DOI: 10.1371/journal.pcbi.1007619

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