Article
Selection Analysis Identifies Clusters of Unusual Mutational Changes in Omicron Lineage BA.1 That Likely Impact Spike Function.
Molecular biology and evolution - 11 Apr 2022
Martin Darren P, Lytras Spyros, Lucaci Alexander G, Maier Wolfgang, Grüning Björn, Shank Stephen D, Weaver Steven, MacLean Oscar A, Orton Richard J, Lemey Philippe, Boni Maciej F, Tegally Houriiyah, Harkins Gordon W, Scheepers Cathrine, Bhiman Jinal N, Everatt Josie, Amoako Daniel G, San James Emmanuel, Giandhari Jennifer, Sigal Alex, Williamson Carolyn, Hsiao Nei-Yuan, von Gottberg Anne, De Klerk Arne, Shafer Robert W, Robertson David L, Wilkinson Robert J, Sewell B Trevor, Lessells Richard, Nekrutenko Anton, Greaney Allison J, Starr Tyler N, Bloom Jesse D, Murrell Ben, Wilkinson Eduan, Gupta Ravindra K, de Oliveira Tulio, Kosakovsky Pond Sergei L
Abstract excerpt
Among the 30 nonsynonymous nucleotide substitutions in the Omicron S-gene are 13 that have only rarely been seen in other SARS-CoV-2 sequences. These mutations cluster within three functionally important regions of the S-gene at sites that will likely impact (1) interactions between subunits of the Spike trimer and the predisposition of subunits to shift from down to up configurations, (2) interactions of Spike...
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