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Mutation and codon bias analysis of the spike protein of Omicron, the recent variant of SARS-CoV-2.

International journal of biological macromolecules - 1 Oct 2023

Lu Yunbiao, Wang Weixiu, Liu Hao, Li Yue, Yan Ge, Franzo Giovanni, Dai Jianjun, He Wan-Ting

Abstract excerpt

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant is a heavily mutated virus and designated as a variant of concern. To investigate the codon usage pattern of this new variant, we performed mutation and codon bias analysis for Omicron as well as for its sub-lineages BA.1 and BA.2 and compared them with the original SARS-CoV-2 and the Delta variant sequences obtained in this study. Our...

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PMID: 37536405
DOI: 10.1016/j.ijbiomac.2023.126080

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