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Article

Spike mutations contributing to the altered entry preference of SARS-CoV-2 omicron BA.1 and BA.2.

Emerging microbes & infections - 1 Dec 2022

Hu Bingjie, Chan Jasper Fuk-Woo, Liu Huan, Liu Yuanchen, Chai Yue, Shi Jialu, Shuai Huiping, Hou Yuxin, Huang Xiner, Yuen Terrence Tsz-Tai, Yoon Chaemin, Zhu Tianrenzheng, Zhang Jinjin, Li Wenjun, Zhang Anna Jinxia, Zhou Jie, Yuan Shuofeng, Zhang Bao-Zhong, Yuen Kwok-Yung, Chu Hin

Abstract excerpt

SARS-CoV-2 B.1.1.529.1 (Omicron BA.1) emerged in November 2021 and quickly became the predominant circulating SARS-CoV-2 variant globally. Omicron BA.1 contains more than 30 mutations in the spike protein, which contribute to its altered virological features when compared to the ancestral SARS-CoV-2 or previous SARS-CoV-2 variants. Recent studies by us and others demonstrated that Omicron BA.1 is less dependent...

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Identifiers

PMID: 36039901
DOI: 10.1080/22221751.2022.2117098
PMCID: PMC9542985

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