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Chronic Viral Mimicry Induction following p53 Loss Promotes Immune Evasion

7 Jan 2025

Abstract excerpt

Abstract Epigenetic therapies facilitate transcription of immunogenic repetitive elements that cull cancer cells through “viral mimicry” responses. Paradoxically, cancer-initiating events also facilitate transcription of repetitive elements. Contributions of repetitive element transcription toward cancer initiation, and the mechanisms by which cancer cells evade lethal viral mimicry responses during tumor...

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PMID: 39776167
DOI: 10.1158/2159-8290.cd-24-0094

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