Article
ATM mutations in patients with hereditary pancreatic cancer.
Cancer discovery - 1 Jan 2012
Roberts Nicholas J, Jiao Yuchen, Yu Jun, Kopelovich Levy, Petersen Gloria M, Bondy Melissa L, Gallinger Steven, Schwartz Ann G, Syngal Sapna, Cote Michele L, Axilbund Jennifer, Schulick Richard, Ali Syed Z, Eshleman James R, Velculescu Victor E, Goggins Michael, Vogelstein Bert, Papadopoulos Nickolas, Hruban Ralph H, Kinzler Kenneth W, Klein Alison P
Abstract excerpt
UNLABELLED: Pancreatic cancers are the fourth most-common cause of cancer-related deaths in the Western world, with >200,000 cases reported in 2010. Although up to 10% of these cases occur in familial patterns, the hereditary basis for predisposition in the vast majority of affected families is unknown. We used next-generation sequencing, including whole-genome and whole-exome analyses, and identified...
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