Article
A GWAS in Idiopathic/Unexplained Infertile Men Detects a Genomic Region Determining Follicle-Stimulating Hormone Levels.
The Journal of clinical endocrinology and metabolism - 14 Jul 2022
Schubert Maria, Pérez Lanuza Lina, Wöste Marius, Dugas Martin, Carmona F David, Palomino-Morales Rogelio J, Rassam Yousif, Heilmann-Heimbach Stefanie, Tüttelmann Frank, Kliesch Sabine, Gromoll Jörg
Abstract excerpt
CONTEXT: Approximately 70% of infertile men are diagnosed with idiopathic (abnormal semen parameters) or unexplained (normozoospermia) infertility, with the common feature of lacking etiologic factors. Follicle-stimulating hormone (FSH) is essential for initiation and maintenance of spermatogenesis. Certain single-nucleotide variations (SNVs; formerly single-nucleotide polymorphisms [SNPs]) (ie, FSHB c.-211G > T,...
Topics
- Humans
- Male
- Follicle Stimulating Hormone
- Genome-Wide Association Study
- Genomics
- Infertility, Male
- Polymorphism, Single Nucleotide
- Retrospective Studies