Article
FSHB and FSHR gene variants exert mild modulatory effect on reproductive hormone levels and testis size but not on semen quality: A study of 2020 men from the general Danish population.
Andrology - 1 Mar 2021
Bang Anne Kirstine, Almstrup Kristian, Nordkap Loa, Priskorn Laerke, Petersen Jørgen Holm, Blomberg Jensen Martin, Krause Marianna, Holmboe Stine Agergaard, Egeberg Palme Dorte Louise, Winge Sofia Boeg, Joensen Ulla Nordström, Olesen Inge Ahlmann, Hvidman Helene Westring, Juul Anders, Rajpert-De Meyts Ewa, Jørgensen Niels
Abstract excerpt
BACKGROUND: Spermatogenesis depends on stimulation by follicle-stimulating hormone (FSH) which binds to FSH receptors (FSHR) on testicular Sertoli cells. Three FSH-related single-nucleotide polymorphisms (SNPs), FSHB -211G>T (rs10835638), FSHR -29G>A (rs1394205) and FSHR 2039A>G (rs6166) affect FSH action, and have been suggested to affect testicular function, but the evidence is uncertain. OBJECTIVE: To describe...
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