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FSHB Transcription is Regulated by a Novel 5' Distal Enhancer With a Fertility-Associated Single Nucleotide Polymorphism.

Endocrinology - 1 Jan 2021

Bohaczuk Stephanie C, Thackray Varykina G, Shen Jia, Skowronska-Krawczyk Dorota, Mellon Pamela L

Abstract excerpt

The pituitary gonadotropins, follicle-stimulating hormone (FSH) and luteinizing hormone, signal the gonads to regulate male and female fertility. FSH is critical for female fertility as it regulates oocyte maturation, ovulation, and hormone synthesis. Multiple genome-wide association studies (GWAS) link a 130 Kb locus at 11p14.1, which encompasses the FSH beta-subunit (FSHB) gene, with fertility-related traits...

Topics

Animals
Female
Follicle Stimulating Hormone, beta Subunit
Gene Expression Regulation
Genetic Predisposition to Disease
Genome-Wide Association Study
Histones
Humans
Infertility, Female
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

NIH 3T3 Cells

Polymorphism, Single Nucleotide

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Open in PubMed Open full text

Identifiers

PMID: 33009549
DOI: 10.1210/endocr/bqaa181
PMCID: PMC7846141

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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