Article
Increased Prevalance of the -211 T allele of follicle stimulating hormone (FSH) beta subunit promoter polymorphism and lower serum FSH in infertile men.
The Journal of clinical endocrinology and metabolism - 1 Jan 2010
Grigorova Marina, Punab Margus, Poolamets Olev, Kelgo Piret, Ausmees Kristo, Korrovits Paul, Vihljajev Vladimir, Laan Maris
Abstract excerpt
CONTEXT: The human FSHB promoter polymorphism (rs10835638; -211 G/T) has been associated with serum FSH in a cohort of young Estonian men. The minor allele carriers had reduced serum FSH (15.7% in GT heterozygotes; 40% in TT homozygotes) compared with GG homozygotes. OBJECTIVE: Because FSH is essential for normal spermatogenesis and fertility, we speculated that abnormalities in FSH action could contribute to...
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