Article
Genetically determined dosage of follicle-stimulating hormone (FSH) affects male reproductive parameters.
The Journal of clinical endocrinology and metabolism - 1 Sept 2011
Grigorova Marina, Punab Margus, Zilaitienė Birutė, Erenpreiss Juris, Ausmees Kristo, Matuleviĉius Valentinas, Tsarev Igor, Jørgensen Niels, Laan Maris
Abstract excerpt
CONTEXT: The detailed role of FSH in contributing to male testicular function and fertility has been debated. We have previously identified the association between the T-allele of the FSHB promoter polymorphism (rs10835638; G/T, -211 bp from the mRNA start) and significantly reduced male serum FSH. OBJECTIVE: In the current study, the T-allele carriers of the FSHB -211 G/T single nucleotide polymorphism...
Topics
- Adolescent
- Alleles
- Body Mass Index
- Cohort Studies
- Estradiol
- Follicle Stimulating Hormone
- Gene Dosage
- Humans