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Article

Local iron deficiency in the substantia nigra directly contributes to hyperlocomotion phenotypes.

Neurobiology of disease - 15 Jun 2022

Wang Zhuo, Huang Yanjun, Zhou Zhihua, Huang Jian, He Yitong, Qiu Pingming

Abstract excerpt

Brain iron is precisely regulated, and disrupted brain iron homeostasis is implicated in neuropsychological disease. Mounting evidence connects the iron status of the substantia nigra (SN) with locomotion-related neural symptomatology. Researchers in this field have long speculated that iron deficiency in the SN directly causes the high-locomotion symptoms observed in neuropsychiatric disorders. However, no...

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PMID: 35304229
DOI: 10.1016/j.nbd.2022.105693

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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