Article

Restless Legs Syndrome: A Network Model of Iron-Dependent Neuromodulation—A Narrative Review

2026-04-15

Abstract excerpt

Restless legs syndrome (RLS) is traditionally conceptualised as a dopamine-responsive sensorimotor disorder; however, new evidence suggests a more complex and heterogeneous neurobiological basis. Findings from neuroimaging, genetic studies, circadian biology, and clinical research indicate that dopaminergic dysfunction occurs within a broader context of neuromodulatory imbalance involving iron metabolism, adenosin...

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Literature Corpus work: 904861f1-c07e-5edb-93e6-348b4ab0e70f
DOI: 10.20944/preprints202604.1068.v1

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