Article

Hypersensitivity of the striatal striosomal dopamine D1 receptor-neuron in a rodent model of restless legs syndrome

2026-01-16

Abstract excerpt

<title>Abstract</title> <p> We hypothesized that Restless Legs Syndrome (RLS) and the restlessness of opioid withdrawal share common neurobiological mechanisms based on the efficacy of µ-opioid receptor (MOR) agonists in RLS and the common RLS-like phenotype of patients with opioid withdrawal. We also hypothesized this involves an increased sensitivity of the striosomal neurons that co-express MORs and dopamine...

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Literature Corpus work: afa85eb3-a301-5809-b0e4-f4d496e439c4
DOI: 10.21203/rs.3.rs-8584406/v1

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