Article
KLHL3 regulates paracellular chloride transport in the kidney by ubiquitination of claudin-8.
Proceedings of the National Academy of Sciences of the United States of America - 7 Apr 2015
Gong Yongfeng, Wang Jinzhi, Yang Jing, Gonzales Ernie, Perez Ronaldo, Hou Jianghui
Abstract excerpt
A rare Mendelian syndrome--pseudohypoaldosteronism type II (PHA-II)--features hypertension, hyperkalemia, and metabolic acidosis. Genetic linkage studies and exome sequencing have identified four genes--with no lysine kinase 1 (wnk1), wnk4, Kelch-like 3 (KLHL3), and Cullin 3 (Cul3)--mutations of which all caused PHA-II phenotypes. The previous hypothesis was that the KLHL3-Cul3 ubiquitin complex acted on the...
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