Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The role of monoubiquitination in endocytic degradation of human ether-a-go-go-related gene (hERG) channels under low K+ conditions.

The Journal of biological chemistry - 25 Feb 2011

Sun Tao, Guo Jun, Shallow Heidi, Yang Tonghua, Xu Jianmin, Li Wentao, Hanson Christian, Wu James G, Li Xian, Massaeli Hamid, Zhang Shetuan

Abstract excerpt

A reduction in extracellular K(+) concentration ([K(+)](o)) causes cardiac arrhythmias and triggers internalization of the cardiac rapidly activating delayed rectifier potassium channel (I(Kr)) encoded by the human ether-a-go-go-related gene (hERG). We investigated the role of ubiquitin (Ub) in endocytic degradation of hERG channels stably expressed in HEK cells. Under low K(+) conditions, UbKO, a lysine-less...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endocytosis
Share to Endosomal Sorting Complexes Required for Transport

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ERG1 Potassium Channel

Share to Ether-A-Go-Go Potassium Channels

Share to Lysosomes

Share to Potassium

Share to Ubiquitin

Share to Ubiquitination

Source

Open in PubMed Open full text

Identifiers

PMID: 21177251
DOI: 10.1074/jbc.M110.198408
PMCID: PMC3057800

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of monoubiquitination in endocytic degradation of human ether-a-go-go-related gene (hERG) channels under low K+ conditions.PMID 21177251Read ↗

Degradation of trafficking-defective long QT syndrome type II mutant channels by the ubiquitin-proteasome pathway.Semantic proximity Read ↗

Decoding polyubiquitin regulation of K <sub>V</sub> 7. 1 functional expression with engineered linkage-selective deubiquitinasesSemantic proximity Read ↗

Regulation of the human ether-a-go-go-related gene (hERG) potassium channel by Nedd4 family interacting proteins (Ndfips).Semantic proximity Read ↗

Nedd4-2-dependent ubiquitylation and regulation of the cardiac potassium channel hERG1.Semantic proximity Read ↗

Ubiquitylation of ion channels.Semantic proximity Read ↗

Extracellular K+ concentration controls cell surface density of IKr in rabbit hearts and of the HERG channel in human cell lines.Semantic proximity Read ↗

Multiubiquitination of TRPV4 reduces channel activity independent of surface localization.Semantic proximity Read ↗

Identification of a Posttranslational Mechanism for the Regulation of hERG1 K+ Channel Expression and hERG1 Current Density in Tumor CellsSemantic proximity Read ↗

Endocytic control of ion channel density as a target for cardiovascular disease.Semantic proximity Read ↗

Short-chain ubiquitination mediates the regulated endocytosis of the aquaporin-2 water channel.Semantic proximity Read ↗

Role of ubiquitin-proteasome degradation pathway in biogenesis efficiency of {beta}-cell ATP-sensitive potassium channels.Semantic proximity Read ↗

Ubiquitination-activating enzymes UBE1 and UBA6 regulate ubiquitination and expression of cardiac sodium channel Nav1.5.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.