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Article

The ‘a, b, c’s of pretangle tau and their relation to aging and the risk of Alzheimer’s Disease

2 Mar 2021

Abstract excerpt

Braak has described the beginnings of Alzheimer's Disease as occurring in the locus coeruleus. Here we review these pretangle stages and relate their expression to recently described normal features of tau biology. We suggest pretangle tau depends on characteristics of locus coeruleus operation that promote tau condensates. We examine the timeline of pretangle and tangle appearance in locus coeruleus. We find...

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PMID: 33674223
DOI: 10.1016/j.semcdb.2020.12.010

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