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Article

L-plastin enhances NLRP3 inflammasome assembly and bleomycin-induced lung fibrosis

1 Mar 2022

Abstract excerpt

Macrophage adhesion and stretching have been shown to induce interleukin (IL)-1β production, but the mechanism of this mechanotransduction remains unclear. Here we specify the molecular link between mechanical tension on tissue-resident macrophages and activation of the NLRP3 inflammasome, which governs IL-1β production. NLRP3 activation enhances antimicrobial defense, but excessive NLRP3 activity causes...

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PMID: 35294888
DOI: 10.1016/j.celrep.2022.110507

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