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Functional characterization of the human Cdk10/Cyclin Q complex

1 Mar 2022

Abstract excerpt

Cyclin-dependent kinases (CDKs) are key players in cell cycle regulation and transcription. The CDK-family member Cdk10 is important for neural development and can act as a tumour suppressor, but the underlying molecular mechanisms are largely unknown. Here, we provide an in-depth analysis of Cdk10 substrate specificity and function. Using recombinant Cdk10/CycQ protein complexes, we characterize RNA pol II CTD,...

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PMID: 35291876
DOI: 10.1098/rsob.210381

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