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Article

Perspective of Cyclin-dependent kinase 9 (CDK9) as a Drug Target

1 May 2012

Abstract excerpt

Deregulation of cyclin-dependent kinases (CDKs) has been associated with many cancer types and has evoked an interest in chemical inhibitors with possible therapeutic benefit. While most known inhibitors display broad selectivity towards multiple CDKs, recent work highlights CDK9 as the critical target responsible for the anticancer activity of clinically evaluated drugs. In this review, we discuss recent...

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PMID: 22571657
DOI: 10.2174/138161212800672750

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