Article
Oncogenic ERBB3 mutations in human cancers.
Cancer cell - 13 May 2013
Jaiswal Bijay S, Kljavin Noelyn M, Stawiski Eric W, Chan Emily, Parikh Chaitali, Durinck Steffen, Chaudhuri Subhra, Pujara Kanan, Guillory Joseph, Edgar Kyle A, Janakiraman Vasantharajan, Scholz Rolf-Peter, Bowman Krista K, Lorenzo Maria, Li Hong, Wu Jiansheng, Yuan Wenlin, Peters Brock A, Kan Zhengyan, Stinson Jeremy, Mak Michelle, Modrusan Zora, Eigenbrot Charles, Firestein Ron, Stern Howard M, Rajalingam Krishnaraj, Schaefer Gabriele, Merchant Mark A, Sliwkowski Mark X, de Sauvage Frederic J, Seshagiri Somasekar
Abstract excerpt
The human epidermal growth factor receptor (HER) family of tyrosine kinases is deregulated in multiple cancers either through amplification, overexpression, or mutation. ERBB3/HER3, the only member with an impaired kinase domain, although amplified or overexpressed in some cancers, has not been reported to carry oncogenic mutations. Here, we report the identification of ERBB3 somatic mutations in ~11% of colon...
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