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Article

Epstein–Barr virus latency programs dynamically sensitize B cells to ferroptosis

11 Mar 2022

Abstract excerpt

SignificanceEpstein-Barr virus (EBV) contributes to Burkitt lymphoma and post-transplant lymphoproliferative disease (PTLD). EBV-transforming programs activate lipid metabolism to convert B cells into immortalized lymphoblastoid cell lines (LCL), a PTLD model. We found that stages of EBV transformation generate lipid reactive oxygen species (ROS) byproducts to varying degrees, and that a Burkitt-like phase of B...

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PMID: 35275790
DOI: 10.1073/pnas.2118300119

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