Article

Epstein-Barr virus latency programs dynamically sensitize B-cells to ferroptosis

2022-02-21

Abstract excerpt

Epstein-Barr virus (EBV) causes 200,000 cancers annually. Upon B-cell infection, EBV induces lipid metabolism to support B-cell proliferation. Yet, little is known about how latent EBV infection, or human B-cell stimulation more generally, alter sensitivity to ferroptosis, a non-apoptotic form of programmed cell death driven by iron-dependent lipid peroxidation and membrane damage. To gain insights, we analyzed li...

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Literature Corpus work: 4aceb3ce-c6b2-5bd4-b78a-fd83c5a2e561
DOI: 10.1101/2022.02.21.481361

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