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Article

A metabolic dependency of EBV can be targeted to hinder B cell transformation

23 May 2024

Abstract excerpt

After infection of B cells, Epstein-Barr virus (EBV) engages host pathways that mediate cell proliferation and transformation, contributing to the propensity of the virus to drive immune dysregulation and lymphomagenesis. We found that the EBV protein EBNA2 initiates nicotinamide adenine dinucleotide (NAD) de novo biosynthesis by driving expression of the metabolic enzyme indoleamine 2,3-dioxygenase 1 (IDO1) in...

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PMID: 38781354
DOI: 10.1126/science.adk4898

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