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Epstein-Barr virus ensures B cell survival by uniquely modulating apoptosis at early and late times after infection

20 Apr 2017

Abstract excerpt

Latent Epstein-Barr virus (EBV) infection is causally linked to several human cancers. EBV expresses viral oncogenes that promote cell growth and inhibit the apoptotic response to uncontrolled proliferation. The EBV oncoprotein LMP1 constitutively activates NFκB and is critical for survival of EBV-immortalized B cells. However, during early infection EBV induces rapid B cell proliferation with low levels of LMP1...

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PMID: 28425914
DOI: 10.7554/elife.22509

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