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Structural basis for HCMV Pentamer receptor recognition and antibody neutralization

11 Mar 2022

Abstract excerpt

Human cytomegalovirus (HCMV) represents the viral leading cause of congenital birth defects and uses the gH/gL/UL128-130-131A complex (Pentamer) to enter different cell types, including epithelial and endothelial cells. Upon infection, Pentamer elicits the most potent neutralizing response against HCMV, representing a key vaccine candidate. Despite its relevance, the structural basis for Pentamer receptor...

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PMID: 35275719
DOI: 10.1126/sciadv.abm2536

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