Article

Vaccine-induced immune thrombotic thrombocytopenia (VITT) is mediated by a stereotyped clonotypic antibody

2022-04-04

Abstract excerpt

<h4>ABSTRACT</h4> Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare thromboembolic complication of adenoviral-vectored SARS-CoV2 vaccines, mediated by antibodies directed against platelet factor 4 (PF4). Given their causal role in VITT, identification of the molecular composition of anti-PF4 antibodies is crucial for developing better diagnostics and treatments. Here, we utilised a novel proteomi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 395cf37f-eb6e-5dae-aebc-4783952200c2
DOI: 10.1101/2022.03.28.22272975

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Vaccine-induced immune thrombotic thrombocytopenia (VITT) is mediated by a stereotyped clonotypic antibodyDOI 10.1101/2022.03.28.22272975Read

Structural characterization of a pathogenic antibody underlying vaccine-induced immune thrombotic thrombocytopenia (VITT)Semantic proximity Read

Reverse engineering of a pathogenic antibody reveals the molecular mechanism of vaccine-induced immune thrombotic thrombocytopeniaSemantic proximity Read

Platelet Factor 4 Antibody Persistence and Long-term Pathogenicity in Vaccine-induced Immune Thrombotic ThrombocytopeniaSemantic proximity Read

<i>de Novo</i> Sequencing of Antibodies for Identification of Neutralizing Antibodies in Human Plasma Post SARS-CoV-2 VaccinationSemantic proximity Read

Incidence of anti-platelet factor4/polyanionic antibodies, thrombocytopenia, and thrombosis after COVID-19 vaccination with ChAdOx1 nCoV-19 in ThaisSemantic proximity Read

The proteomic toolbox for identification, quantification, and characterization of polyclonal antibodiesSemantic proximity Read

Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing.Semantic proximity Read

Functional Antibodies in COVID-19 Convalescent PlasmaSemantic proximity Read

NETosis and thrombosis in vaccine-induced immune thrombotic thrombocytopeniaSemantic proximity Read

Comprehensive profiling of antibody responses to the human anellome using programmable phage displaySemantic proximity Read

Deficient humoral responses and disrupted B-cell immunity are associated with fatal SFTSV infection.Semantic proximity Read

De novo identification of VRC01 class HIV-1-neutralizing antibodies by next-generation sequencing of B-cell transcripts.Semantic proximity Read