Article

A survey of opsin localization, glycosylation, and light/chromophore influence on degeneration in 26 <i>rhodopsin</i> -associated retinitis pigmentosa models

2025-07-24

Abstract excerpt

<h4>Purpose</h4> Mutations in rhodopsin (RHO) cause autosomal dominant retinitis pigmentosa (RP), which has multiple clinical subclasses, including class B1 (“sector”) RP in which the asymmetric retinal degeneration (RD) suggests an environmental influence. The pathogenic mechanisms of most class B1 mutations are uncharacterized. We generated new animal models of RHO -associated RP to examine RHO expression, lo...

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Literature Corpus work: e71777a0-51d6-5d1c-8093-2273059c1a0e
DOI: 10.1101/2025.07.23.665973

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