Article
Commonalities and differences in the mutational signature and somatic driver mutation landscape across solid and hollow viscus organs.
Oncogene - 1 Sept 2023
Ng Aik Seng, Chan Dedrick Kok Hong
Abstract excerpt
Advances in sequencing have revealed a highly variegated landscape of mutational signatures and somatic driver mutations in a range of normal tissues. Normal tissues accumulate mutations at varying rates ranging from 11 per cell per year in the liver, to 1879 per cell per year in the bladder. In addition, some normal tissues are also comprised of a large proportion of cells which possess driver mutations while...
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